This blog describes findings that may enable you to rejuvenate your stem cells using low-cost approaches available right now.

The encouraging news is that we may be able to regenerate our existing pool of stem cells today. The significance of this cannot be overstated.

If we replenish our pool of healthy stem cells, we my regain the ability to repopulate our tissues with fresh functional cells. The good news is that certain nutrients that many of you already supplement with have stem cell renewing properties. This can buy precious time as ongoing research develops systemic stem cell rejuvenation therapies envisioned 20 years ago.

Using several lines of preclinical evidence from the scientific literature, we can outline a rational approach hat could allow us to reactivate aging stem cells.

Stem Cells are Retained with Age

Many stem cells are retained as we age and have the capacity to self-renew and differentiate into mature functional cells. Several factors that drive the aging process also reduce the regenerative potential of stem cells and contribute to worsening of age-relate conditions.

Summary Overview

Adult stem cells lose their ability to repopulate tissues with fresh functional cells. The result is systemic deterioration of tissues throughout our aging bodies.

Treatment that are currently being used to slow aging, such as boosting AMPK and sirtuins appear likely to facilitate

Another property to improve stem cell function is Metformin, an FDA-approved drug with potent AMPK-activating properties. It and other compounds that activate AMPK represent a potential option for induction of stem cell rejuvenation in adult stem cell therapies.

Source: Excerpts from Life Extension Magazine March 2020

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Time-restricted eating, a type of intermittent fasting, promoted significant health benefits in patients with metabolic syndrome, a pilot study published in the journal Cell Metabolism reported.

The study suggests that eating only within a 10-hour window, and not eating for a 14-hour stretch of time, can benefit individuals at risk for type II diabetes, heart disease and stroke.

A research team from the University of San Diego, and the Salk Institute for Biological Studies, enrolled 19 participants, 13 men and six women, who had been diagnosed with metabolic syndrome. For 12-week period, their eating was restricted to a maximum of 10-hours daily, during which time they could eat anything they wanted in whatever quantities they wished.

At baseline, the participants eating window, defined as the interval during which 95% of calories were consumed, was about 15 hours every day.

At the end of the study, the 29% reduction in the eating interval to 10 hours daily, was associated with a 3% reduction in weight, BMI, and percent of body fat, and a 4% reduction in waist circumference. Individuals also reported that they had more restful sleep. Many also saw lower cholesterol and blood sugar levels.

Note: “Time-restricted eating is a potentially powerful lifestyle intervention tht cn be added to standard medical practice to treat metabolic syndrome,” the author stated

Source: Life Extension Magazine, March 2020

CoQ10 Continues to Impress Researchers

Life Extension informed readers about coenzyme Q10 (CoQ10) in 1983. Back in those early years, Americans did not know about CoQ10 even though it was widely prescribed in Japan to treat heart failure.

As clinical data mount about the ability of CoQ10 to improve heart, brain and kidney function, it has become a popular dietary supplement in the U.S. New findings reveal improved bone desnsity, reduced inflammation, and protection against diabetic complications. But not everyone is garnering these benefits.

With age, the body’s ability to fully utilize most commercial sources of CoQ10 (ubiquinene) diminishes. When using ubiquinol form, more CoQ10 is absorbed and made bioavailable to tissues throughout the body. In younger people CoQ10 is abundantly produced naturally. With age and/or use of statin drugs, internal production of coenzyme Q10 plummets. The adverse consequence is systemic cellular energy depletion.

Supplementation with ubiquinol form of CoQ10 can restore youthful CoQ10 blood levels and maximize its health promoting effects.

Vital for Overall Health

1. Coenzyme Q10 (CoQ10) is an important compound requrired for the processes that supply energy to cells and to protect from the damaging effects of free radicals.
2. In addition to reducing side effects of cholesterol-lowering statin drugs, CoQ10 has been linked to protection from cardio-vascular disease, neurological conditions, age-related bone loss, metabolic disorders like obesity and diabetes and more.
3. There are two forms of CoQ10: ubiquinol and ubiquinone. Studies have shown that ubiquinol is more easily absorbed making it the preferred type in supplements.
4. Supplemention with 100mg to 400mg per day of ubiquinol CoQ10 is safe and has been associated with health benefits in various human studies. Higher doses (400 mg/day) are often prescribed by cardiologists for heart failure patients.
   
   Summary

Coenzyme Q10 has been linked to better cardiovascular, neurological, metabolic and bone health

CoQ10 comes in two forms, ubiquinol and ubiquinone, but they are not the same. Ubiquinol is the form responsible for its health benefits and it’s more easily absorbed than ubquinone.

While younger people can benefit from either form, maturing individuals should consider ubiquinol because their internal production of CoQ10 is so deficient.

CoQ10 levels plummet in response to statin drug use. Normal, aged people already have less-than-optimal CoQ10 blood levels.

Taking 100 mg and more of the ubiquinol form of coenzyme Q10 with a fatty meal can help older individuals lead a longer, healthier life.

Source: Excerpts from Life Extension Magazine Winter Edition 2019-2020

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For thousands of years, turmeric root has been used as a tratitional Indian medicine. The turmeric spice, which gives curry its golden color, has been recognized for wide-ranging health benefits. The most beneficial compounds in turmeric are curcuminoids, which include curcumin and related compounds.

One animal study showed lifespan extension up to 26% with curcumin supplementation. But, there’s been a major problem that limits practical use: curcuminoids have poor oral bioavailability. That means a large portion of curcumin taken orally never gets absorbed into the blood stream and doesn’t reach the tissues.

Scientists have made a major advance in solving this problem. At Life Extension, we have perfected a patented form of curcumin that dramatically boosts its bioavailability. For the fist time, people have the opportunity to realize the potential of curcumin to benefit whole-body health, slow certain aging processes, and reduce risks for age-related disorders.

Extending Healthy Lifespan

By improving the absorption and tissue distribution of curcumin, it is now possible to maximize its benefits in fighting specific diseases. Perhaps the most remarkable ability curcumin has shown in research is to

How does it work? In studies of longevity, a handful of key mechanisms keep coming up. Each of the following has repeatedly been shown to help slow the aging process and extend healthy lifespan:

• Reducing chronic, low-grade inflammation
• Increasing activity of sirtuins specialized proteins that regulate cellular health.
• Decreasing activity of mToR, a protein associated with rapid aging and cancer.
• Enhancing activity of the enzyme AMPK, which improves metabolism.
• Boosting autophagy, the cellular “recycling” process that helps keep cells rejuvenated, and
• Protecting against tissue damage caused by glycation, when sugars attach to proteins and fats.

Curcumin positively affects every one of these targets.

Curcumin’s Effects on the Diseases of Aging

Curcumin has also been shown to be beneficial against many specific diseases and conditions. Among them are some of the most common and well-studied disorders, including the following;

• Neurodegenerative Diseases; age-related neudegenerative diseases and dementias, including Alzheimers disease.
• Cancer: In addition to reducing chronic inflammation and oxidative damage caused by free radicals, both of which contribute to the developemnt of cancer, curcumin has been shown to have anti-cancer effects.
  
  

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• Obesity: Being overweight increases the risks of developing conditions like heart disease, stroke, cancer, and diabetes. By improving metabolic function and reducing inflammation, curcumin helps ameliorate some of these effects. it has also been found to aid in weight loss, as seen with calorie-restricted diets and exercise.
• Metabolic Syndrome: Metabolic Syndrome refers to a group of disorders, including elevated levels of blood surag, abnormal lipid profiles, high blood pressure, and excess belly fat. Curcuin has a powerful impact on metabolism, helping to reduce these risk factors.
• Cardiovascular Disease; Curcumin protects the heart and blood vessels in numerous ways. As noted, it can reduce risk factors for cardiovascular disease, like obesity, high blood pressure, and abnormal blood lipid levels. Curcumin also does much more. Research has shown that it can reduce pathological changes in the blood vessels and heart that contribut to atherosclerosis, aneurysm formation ad heart dysfunction.
• Arthritis: A powerful anti-inflammatory, curcumin is a way to treat painful ailments related to inflamation. One of the most common of thees conditions is osteoarthritis, the degenerative joint disease that occurs frequently in older age.

• Depression and Anxiety; Several studies have found that curcumin can help control symptoms of major deperssion.

• Source: Excerpts form Life Extension Magazine, February 2020

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Wide-Ranging Benefits of SAMe

Since Life Extension first introduced SAMe (S-Adenosyl-Methionine) back in 1997, it’s become a popular for boosting mood.

In addition to fighting depression, SAMe also stimulates the production of new cartilage in animals and improves symptoms and functioning in osteoarthritis patients.

In a recent study SAMe was shown to increase lifespan of yeast. What’s the common link between these benefits and SAMe? SAMe is a cofactor in a process called DNA methylation, which regulates gene expression. In doing so, it can help fight against some of the causes of age-related disease-and it may prolong life itself.

Osteoarthritis Improvement

Osteoarthritis is the most common and disabling joint disease. It can cause loss of the cushioning cartilate that eases joint movement, eventually damaging underlying bone.

It’s chronic and has no known cure. But there is new hope for treating it. Numerous studies have shown that SAMe may help treat osteoarthritis. Among the results are:

• SAMe stimulates production of new cartilage in animals. This is crucial to slowing or reversing the progress of osteoarthritis.
• In short, and long-term studies, patients reported improvement of symptoms.
• Osteoarthritis patients treated with SAMe experienced pain relief as strong as that delivered by non-steroidal anti-inflammatory drugs
• A meta-analysis of 11 studies showed that SAMe improved functioning in arthritis patients and was comparable to NSAIDs for pain without the side effects common with NSAIDs.

Depression

Clinical depression affects more than 16% of U.S. adults over a lifetime. Stress is a contributor to mood and anxiety disorders. Researchers have found that it drives epigenetic changes in the brain that can alter normal methylation patterns. In fact, abnormal methylation has been linked to depression and mood disorders in multiple ways:

• Prenatal and early childhood exposure to a mother’s depression affects methylation patterns in the infant’s brain.
• Childhood trauma leads to methlation defects, which can be related to long-term and mental health problems.
• Altered methylation is seen in people at high genetic risk for mood disorders, including bipolar and major depression, even before they develop symptoms.

Prolonging Life

Methylation isn’t just linked to the development of age-related diseases. It also has a diect impact on lifespan itself. Studies show that aging is associated with alterations in DNA methylation.

What You Need to Know

How SAMe Helps our Genes Fight Disease

• Humans have about 20,000 genes. Our bodies turn them on or off as necessary.
• One of the main switches that modulate the way genes are expressed is a process called methylation, in which methyl groups are added to the DN.
• The nutrient SAMe (S-AdensylMethionine) is the body’s preferred methyl donor.
• If we don’t have enough of it, the body cannot methylate properly.
• Two seemingly unrelated conditions osteoarthritis and clinical depression, both involve improper methylation. In human studies, both are improved by treatment with SAMe.
• Preclinical studies indicate that increased SAMe also contributes to longer life and improved health.

Source: Excerpts for Life Extension Magazine February 2020

Life Extension first introduced SAMe in 1997. Since then, researchers around the world have continued to discover the impressive benefits.

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Vitamin K promotes Healthy Blood Sugar Metabolism

Type II diabetes isn’t curable, but it is preventable, given the right combination of lifestyle and nutritional choices.

There is no cure for type II diabetes. But there is new hope for the 21 million adults living with it.

Recent research has shown that Vitamin K plays an important role in glucose metabolism. That can help diabetics avoid the high blood sugar that damages the eyes, kidneys, nerves and heart.

Vitamin K may also help prevent the onset of type II diabetes.

Vitamin K is best known for helping blood property clot, maintaining bone density, and preventing vascular calcifications. But, its benefits go far beyond that.

Several large scale studies have analyzed the association between vitamin K nd type II diabetes, examining more than 40,000 people in total Together, these studies show that increased intke of vitamin k, is linked to a reduced risk of developing type II diabetes.

SUMMARY

Type II diabetes isn’t curable, but t is preventable, given the right combination of lifestyle and nutritional choices. There is growing evidence that those with higher intake and blood levels of vitamin K (in the form of both K1 and K2) have substantially reduced risks of developing type II diabetes.

Studies show that people taking vitamin K hve improved glucose metabolism, improved insulin sensitivity, and lower body fat, all of which protect against type II diabetes and metabolic syndrome.

Increasing vitamin K can also benefit those who already have diabetes by keeping damaging high blood sugar under control.

Source: Life Extension Magazine, January, 2020

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What is vitamin K1?

Vitamin K1 is the most common form of vitamin K. It is found in leafy green vegetables. Vitamin K promotes heart, bone and arterial health.

Why did we add vitamin K2?

Vitamin K2 has been found to be up to 6 times more bioavailable than K1 and to remain active in the body for a longer period of time.

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Life Extension receives many inquiries about stem cell infusion therapies offered in the United States and other countries. Our current view from small human trials is that there may be a benefit to infusions of exosomes that are naturally secreted from healthy stem cells.

Stem cell exosomes have regenerative properties that help restore functionsl cells needed to maintain tissue and organ viability. Overlooked when considering exosome treatments is the ability to rejuvenate existing stem cell pools utilizing approaches many of your already follow.

This includes activating AMPK and restoring youthful levels of sirtuins and NAD.

As a side note, we retain stem cells as we age.

• Stem cells are capable of self-renewal
• Stm cells differentiate into functional (somatic) tissue cells
• The number of stem cells may not greatly decrease with age
• Aging reduces regenerative potential of stem cells
• Stem cell senescence contributes to age-related conditions

(KhorraminejadShirazi M, et al. Aging and stem cell therapy: AMPK as an applicable pharmacological target for rejuvenation of aged stem cells and achieving efficacy in stem cell therapy. Hernatol Oncol Stem Cell Ther: 2017)

WHAT YOU NEED TO KNOW

NAD+ for Healthy Longevity

• NAD+ (nicotinamide adenine dinucleotide) is an essential cofactor for hundreds of cellular processes.
• Sirtruins, cellular defenders linked to longer life and protection from disease, require optimal NAD+ levels to function.
• Levels of NAD+ drop with age, accelerating aging. Nicotinamide riboside helps replenish NAD+ levels
• Boostine NAD+ has been tied to improved mitochondrial function, healthier stem cells that rejuvenate tissues, and increased longevity
• Maximizing NAD+ also protects tissues from the effects of age and may reduce risk for age-related diseases such as cognitive decline, cardiovascular disease, and metabolic disease.

SUMMARY

NAD+ is a critical component of a healthy aging program.

Every cell requires it for hundreds of processes. These include activity of sirtuins, cellular guardians linked to prolonged lifespan ahd healthspan.

NAD+ levels and sirtuin expression diminish with advancing age, accelerating aging processes and degenerative disease risk.

Nicotinamide riboside is a compound that increases cellular NAD+ levels, enhancing sirtuin activity. New reserch has found that maintaining more youthful NAD levels can slow certain aspects of biological aging.

NAD+ also improves the health of stem cells that can replace dead and dying cells and keep vital tissues function.

This not only extends lifespan, but also helps reduce the risk for metbolic disease, obesity, crdiovasculr disease, cognitive dysfunction, and more.

Source: Excerpts from Life Extension Magazine, February 2020

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