Life Extension receives many inquiries about stem cell infusion therapies offered in the United States and other countries. Our current view from small human trials is that there may be a benefit to infusions of exosomes that are naturally secreted from healthy stem cells.
Stem cell exosomes have regenerative properties that help restore functionsl cells needed to maintain tissue and organ viability. Overlooked when considering exosome treatments is the ability to rejuvenate existing stem cell pools utilizing approaches many of your already follow.
This includes activating AMPK and restoring youthful levels of sirtuins and NAD.
As a side note, we retain stem cells as we age.
- Stem cells are capable of self-renewal
- Stm cells differentiate into functional (somatic) tissue cells
- The number of stem cells may not greatly decrease with age
- Aging reduces regenerative potential of stem cells
- Stem cell senescence contributes to age-related conditions
(KhorraminejadShirazi M, et al. Aging and stem cell therapy: AMPK as an applicable pharmacological target for rejuvenation of aged stem cells and achieving efficacy in stem cell therapy. Hernatol Oncol Stem Cell Ther: 2017)
WHAT YOU NEED TO KNOW
NAD+ for Healthy Longevity
- NAD+ (nicotinamide adenine dinucleotide) is an essential cofactor for hundreds of cellular processes.
- Sirtruins, cellular defenders linked to longer life and protection from disease, require optimal NAD+ levels to function.
- Levels of NAD+ drop with age, accelerating aging. Nicotinamide riboside helps replenish NAD+ levels
- Boostine NAD+ has been tied to improved mitochondrial function, healthier stem cells that rejuvenate tissues, and increased longevity
- Maximizing NAD+ also protects tissues from the effects of age and may reduce risk for age-related diseases such as cognitive decline, cardiovascular disease, and metabolic disease.
SUMMARY
NAD+ is a critical component of a healthy aging program.
Every cell requires it for hundreds of processes. These include activity of sirtuins, cellular guardians linked to prolonged lifespan ahd healthspan.
NAD+ levels and sirtuin expression diminish with advancing age, accelerating aging processes and degenerative disease risk.
Nicotinamide riboside is a compound that increases cellular NAD+ levels, enhancing sirtuin activity. New reserch has found that maintaining more youthful NAD levels can slow certain aspects of biological aging.
NAD+ also improves the health of stem cells that can replace dead and dying cells and keep vital tissues function.
This not only extends lifespan, but also helps reduce the risk for metbolic disease, obesity, crdiovasculr disease, cognitive dysfunction, and more.
Source: Excerpts from Life Extension Magazine, February 2020
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